Ion channel regulation of intracellular calcium and airway smooth muscle function.

نویسندگان

  • Jose F Perez-Zoghbi
  • Charlotta Karner
  • Satoru Ito
  • Malcolm Shepherd
  • Yazan Alrashdan
  • Michael J Sanderson
چکیده

Airway hyper-responsiveness associated with asthma is mediated by airway smooth muscle cells (SMCs) and has a complicated etiology involving increases in cell contraction and proliferation and the secretion of inflammatory mediators. Although these pathological changes are diverse, a common feature associated with their regulation is a change in intracellular Ca(2+) concentration ([Ca(2+)](i)). Because the [Ca(2+)](i) itself is a function of the activity and expression of a variety of ion channels, in both the plasma membrane and sarcoplasmic reticulum of the SMC, the modification of this ion channel activity may predispose airway SMCs to hyper-responsiveness. Our objective is to review how ion channels determine the [Ca(2+)](i) and influence the function of airway SMCs and emphasize the potential of ion channels as sites for therapeutic approaches to asthma.

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عنوان ژورنال:
  • Pulmonary pharmacology & therapeutics

دوره 22 5  شماره 

صفحات  -

تاریخ انتشار 2009